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Prednisone and azathioprine in patients with inflammatory cardiomyopathy: systematic review and meta‐analysis

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Chronic non‐viral myocarditis, also called inflammatory cardiomyopathy, can be treated with immune suppression on tops of optimal medical therapy (OMT) for heart failure, using a combination of prednisolone and azathioprine… Click to show full abstract

Chronic non‐viral myocarditis, also called inflammatory cardiomyopathy, can be treated with immune suppression on tops of optimal medical therapy (OMT) for heart failure, using a combination of prednisolone and azathioprine (IPA). However, there has been inconsistency in the effects of immunosuppression treatment. This meta‐analysis is the first to evaluate all available data of the effect of this treatment on left ventricular ejection fraction (LVEF) and the combined clinical endpoint of cardiovascular mortality and/or heart transplantation‐free survival.

Keywords: prednisone azathioprine; inflammatory cardiomyopathy; meta analysis

Journal Title: ESC Heart Failure
Year Published: 2020

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