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Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension

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Hypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In… Click to show full abstract

Hypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In patients with resistant hypertension, we compared the changes in cardiac parameters between two strategies based on sequential nephron blockade (NBD) with a combination of diuretics or sequential reninā€angiotensin system blockade (RASB).

Keywords: patients resistant; nephron blockade; sequential nephron; resistant hypertension; hypertension; function

Journal Title: ESC Heart Failure
Year Published: 2020

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