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Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof‐of‐concept study

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Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine–isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF).… Click to show full abstract

Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine–isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof‐of‐concept study aimed to evaluate early evidence of efficacy, safety, and feasibility of H‐ISDN compared with standard of care in CRS.

Keywords: proof concept; cardiorenal syndrome; concept study

Journal Title: ESC Heart Failure
Year Published: 2020

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