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Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice

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In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non‐steroidal mineralocorticoid receptor… Click to show full abstract

In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non‐steroidal mineralocorticoid receptor antagonist finerenone limits the progression of heart failure in ovariectomized (OVX) mice with metabolic disorders.

Keywords: heart; receptor blockade; heart failure; mineralocorticoid receptor; finerenone

Journal Title: ESC Heart Failure
Year Published: 2021

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