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Knockdown of XIST up‐regulates 263294miR‐340‐5p to relieve myocardial ischaemia–reperfusion injury via inhibiting cyclin D1

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Long non‐coding RNAs (lncRNAs) are known to participate in various human diseases, while the role of X inactive‐specific transcript (XIST) binding microRNA‐340‐5p (miR‐340‐5p) remains seldom studied. We aim to identify… Click to show full abstract

Long non‐coding RNAs (lncRNAs) are known to participate in various human diseases, while the role of X inactive‐specific transcript (XIST) binding microRNA‐340‐5p (miR‐340‐5p) remains seldom studied. We aim to identify the role of the XIST/miR‐340‐5p/cyclin D1 (CCND1) axis in the myocardial ischaemia–reperfusion injury (MIRI).

Keywords: xist; ischaemia reperfusion; reperfusion injury; myocardial ischaemia

Journal Title: ESC Heart Failure
Year Published: 2021

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