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Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation

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Pressure overload (PO) and volume overload (VO) lead to concentric or eccentric hypertrophy. Previously, we could show that activation of signalling cascades differ in in vivo mouse models. Activation of… Click to show full abstract

Pressure overload (PO) and volume overload (VO) lead to concentric or eccentric hypertrophy. Previously, we could show that activation of signalling cascades differ in in vivo mouse models. Activation of these signal cascades could either be induced by intrinsic load sensing or neuro‐endocrine substances like catecholamines or the renin‐angiotensin‐aldosterone system.

Keywords: different activation; preload afterload; activation mapks; akt gsk3; gsk3 preload; mapks akt

Journal Title: ESC Heart Failure
Year Published: 2022

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