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Biomarker changes as surrogate endpoints in early‐phase trials in heart failure with reduced ejection fraction

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No biomarker has achieved widespread acceptance as a surrogate endpoint for early‐phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated… Click to show full abstract

No biomarker has achieved widespread acceptance as a surrogate endpoint for early‐phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent morbidity/mortality in HF with reduced ejection fraction (HFrEF).

Keywords: heart failure; early phase; ejection fraction; heart; reduced ejection

Journal Title: ESC Heart Failure
Year Published: 2022

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