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In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)‐bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. Besides shear… Click to show full abstract
In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)‐bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. Besides shear stress, high‐density lipoprotein (HDL) stimulates endothelial cells to increased production of NO via phosphorylation of endothelial nitric oxide synthase (eNOS). For patients with heart failure with reduced ejection fraction, earlier studies demonstrated a positive impact of exercise training (ET) on HDL‐mediated eNOS activation. The study aims to investigate the influence of ET on HDL‐mediated phosphorylation of eNOS in HFpEF patients.
Journal Title: ESC Heart Failure
Year Published: 2022
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