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Heart failure with preserved ejection fraction (HFpEF) is one of the most rapidly growing cardiovascular health burden worldwide, but there is still a lack of understanding about the HFpEF pathophysiology.… Click to show full abstract
Heart failure with preserved ejection fraction (HFpEF) is one of the most rapidly growing cardiovascular health burden worldwide, but there is still a lack of understanding about the HFpEF pathophysiology. The nitric oxide (NO) signalling pathway has been identified as a potential key element. The aim of our study was to investigate markers of NO metabolism [l‐arginine (l‐Arg), homoarginine (hArg), and asymmetric and symmetric dimethylarginine (ADMA and SDMA)], additional biomarkers [N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), endothelin‐1 (ET‐1), mid‐regional pro‐adrenomedullin (MR‐proADM), copeptin, and high‐sensitivity C‐reactive protein (hsCRP)], and the endothelial function in an integrated approach focusing on associations with clinical characteristics in patients with HFpEF.
Journal Title: ESC Heart Failure
Year Published: 2022
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