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Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure

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Diabetes mellitus is associated with worse outcomes and lower attainment of disease‐modifying therapies in patients with heart failure with reduced ejection fraction (HFrEF). This post hoc analysis of TRANSITION compared… Click to show full abstract

Diabetes mellitus is associated with worse outcomes and lower attainment of disease‐modifying therapies in patients with heart failure with reduced ejection fraction (HFrEF). This post hoc analysis of TRANSITION compared the patterns of tolerability and uptitration of sacubitril/valsartan in patients with HFrEF stabilized after hospital admission due to acute decompensated HF depending on the presence or absence of diabetes as a co‐morbidity.

Keywords: sacubitril valsartan; heart failure; influence diabetes; failure influence; heart

Journal Title: ESC Heart Failure
Year Published: 2022

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