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Dapagliflozin reduces pulmonary vascular damage and susceptibility to atrial fibrillation in right heart disease

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Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have made considerable progress in the field of heart failure, but their application in arrhythmia remains to be in‐depth. Right heart disease (RHD) often leads… Click to show full abstract

Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have made considerable progress in the field of heart failure, but their application in arrhythmia remains to be in‐depth. Right heart disease (RHD) often leads to right heart dysfunction and is associated with atrial fibrillation (AF). Here, we explored the possible electrophysiologic effect of dapagliflozin (a type of SGLT2is) in the development of AF in rats with RHD.

Keywords: right heart; atrial fibrillation; heart disease; heart

Journal Title: ESC Heart Failure
Year Published: 2022

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