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SGLT2 inhibitor therapy for transthyretin amyloid cardiomyopathy: early tolerance and clinical response to dapagliflozin

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Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) improve clinical outcomes in heart failure patients with reduced and preserved left ventricular ejection fraction (LVEF), but have not yet been investigated in transthyretin amyloid… Click to show full abstract

Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) improve clinical outcomes in heart failure patients with reduced and preserved left ventricular ejection fraction (LVEF), but have not yet been investigated in transthyretin amyloid cardiomyopathy (ATTR‐CM). This study aimed to evaluate tolerability, clinical outcomes, and changes in NT‐proBNP levels and glomerular filtration rate (GFR) in ATTR‐CM patients treated with dapagliflozin.

Keywords: amyloid cardiomyopathy; inhibitor therapy; transthyretin amyloid; sglt2 inhibitor

Journal Title: ESC Heart Failure
Year Published: 2022

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