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MicroRNA‐494 regulates high glucose‐induced cardiomyocyte apoptosis and autophagy by PI3K/AKT/mTOR signalling pathway

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Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes. However, the mechanism of DCM is not fully understood. Studies have confirmed that certain microRNAs (miRNAs/miRs) are key… Click to show full abstract

Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes. However, the mechanism of DCM is not fully understood. Studies have confirmed that certain microRNAs (miRNAs/miRs) are key regulators of DCM. The aim of this study was to investigate the role and mechanism of microRNA (miR)‐494 in cardiomyocyte apoptosis and autophagy induced by high glucose (HG).

Keywords: microrna 494; high glucose; cardiomyocyte apoptosis; apoptosis autophagy

Journal Title: ESC Heart Failure
Year Published: 2023

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