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Fibrosis‐4 index identifies worsening renal function associated with adverse outcomes in acute heart failure

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Worsening renal function (WRF) often develops during heart failure (HF) treatment. However, prognostic implications of WRF in acute HF remain controversial, and risk stratification of WRF is challenging. Although the… Click to show full abstract

Worsening renal function (WRF) often develops during heart failure (HF) treatment. However, prognostic implications of WRF in acute HF remain controversial, and risk stratification of WRF is challenging. Although the fibrosis‐4 index (FIB‐4) was initially established as a liver fibrosis marker, recent studies show that high FIB‐4 is associated with venous congestion and poor prognosis in acute HF. This study aimed to evaluate whether FIB‐4 could identify prognostically relevant and non‐relevant WRF in patients with acute HF.

Keywords: heart failure; worsening renal; heart; renal function; fibrosis

Journal Title: ESC Heart Failure
Year Published: 2023

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