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Immediate pharmacotherapy intensification after cardiac resynchronization therapy: incidence, characteristics, and impact

Cardiac resynchronization therapy (CRT) is an established treatment for drug‐refractory heart failure (HF) in patients with left bundle branch block (LBBB). Acute haemodynamic improvement after CRT implantation may enable the… Click to show full abstract

Cardiac resynchronization therapy (CRT) is an established treatment for drug‐refractory heart failure (HF) in patients with left bundle branch block (LBBB). Acute haemodynamic improvement after CRT implantation may enable the intensification of HF medication soon thereafter. Immediate pharmacotherapy intensification (IPI) after CRT implantation achieves a synergetic effect, possibly leading to a better prognosis. This study aimed to explore the incidence, characteristics, and impact of IPI on real‐world outcomes among CRT recipients with a history of hospitalization for acute HF.

Keywords: cardiac resynchronization; resynchronization therapy; incidence characteristics; pharmacotherapy intensification; intensification; immediate pharmacotherapy

Journal Title: ESC Heart Failure
Year Published: 2024

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