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The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach

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Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of… Click to show full abstract

Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine the association between circulating cathepsin D levels and clinical outcomes in patients with HF and to investigate the biological settings that induce the release of cathepsin D in HF.

Keywords: role cathepsin; cathepsin; heart failure

Journal Title: European Journal of Heart Failure
Year Published: 2019

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