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Sex differences in mineralocorticoid receptor antagonist trials: a pooled analysis of three large clinical trials

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Women with heart failure (HF) are under‐represented in individual randomized clinical trials (RCTs). Little is known about sex‐specific treatment effects in HF medications. We evaluated sex differences in the response… Click to show full abstract

Women with heart failure (HF) are under‐represented in individual randomized clinical trials (RCTs). Little is known about sex‐specific treatment effects in HF medications. We evaluated sex differences in the response to mineralocorticoid receptor antagonists (MRAs) in major HF MRA trials, including a broad spectrum of left ventricular ejection fraction (LVEF).

Keywords: sex differences; mineralocorticoid receptor; sex; differences mineralocorticoid; clinical trials

Journal Title: European Journal of Heart Failure
Year Published: 2020

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