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Natriuretic peptide‐based inclusion criteria in heart failure with preserved ejection fraction clinical trials: insights from PARAGON‐HF

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Natriuretic peptides (NPs) are now routinely incorporated as key inclusion criteria in clinical trials of heart failure with preserved ejection fraction (HFpEF) as objective measures of risk. An early amendment… Click to show full abstract

Natriuretic peptides (NPs) are now routinely incorporated as key inclusion criteria in clinical trials of heart failure with preserved ejection fraction (HFpEF) as objective measures of risk. An early amendment in PARAGON‐HF required all participants to have elevated NP concentrations, but some were enrolled pre‐amendment, providing a unique opportunity to understand the influence of enrolment pathway in HFpEF clinical trials.

Keywords: failure preserved; heart failure; inclusion criteria; clinical trials

Journal Title: European Journal of Heart Failure
Year Published: 2022

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