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Sodium–glucose cotransporter 2 inhibitors (SGLT2i) may induce an early post‐initiation decrease of estimated glomerular filtration rate (eGFR), which does not impact the SGLT2i benefits. The occurrence, characteristics, determinants, and clinical… Click to show full abstract
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) may induce an early post‐initiation decrease of estimated glomerular filtration rate (eGFR), which does not impact the SGLT2i benefits. The occurrence, characteristics, determinants, and clinical significance of an initial eGFR change among patients with heart failure with reduced ejection fraction require further study. In this study we aimed to describe eGFR change from randomization to week 4 (as percent of change relative to randomization) and assess its impact in EMPEROR‐Reduced.
Journal Title: European Journal of Heart Failure
Year Published: 2022
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