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Effects of steroidal mineralocorticoid receptor antagonists on acute and chronic estimated glomerular filtration rate slopes in patients with chronic heart failure

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Steroidal mineralocorticoid receptor antagonists (MRAs) form a cornerstone of the management of heart failure (HF), but little is known about the long‐term effects of MRA therapy on kidney function. We… Click to show full abstract

Steroidal mineralocorticoid receptor antagonists (MRAs) form a cornerstone of the management of heart failure (HF), but little is known about the long‐term effects of MRA therapy on kidney function. We evaluated acute and chronic estimated glomerular function (eGFR) slopes in the two largest completed trials testing steroidal MRAs in chronic HF.

Keywords: heart failure; heart; mineralocorticoid receptor; receptor antagonists; steroidal mineralocorticoid

Journal Title: European Journal of Heart Failure
Year Published: 2022

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