The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na+ overload… Click to show full abstract
The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na+ overload and reduce oxidative stress in heart failure (HF). We examined if treatment with the β3 AR agonist mirabegron increases LVEF in patients with HF.
Keywords:
agonist;
trial;
first man;
heart failure
Journal Title: European Journal of Heart Failure
Year Published: 2017
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Journal Title: European Journal of Heart Failure
Year Published: 2017
Link to full text (if available)
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recommendations!