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The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP‐mediated conditional gene knock‐out or knock‐in can be used for… Click to show full abstract
The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP‐mediated conditional gene knock‐out or knock‐in can be used for the genetic manipulation of germinal center B cells in vivo. Here we present a novel allele, Cγ1‐CreERT2, that allows for timed activation of Cre recombinase in a small fraction of germinal center B cells. This allele will be useful to study normal and malignant germinal center B cell development in vivo.
Keywords:
germinal center;
novel allele;
allele inducible;
inducible cre;
center cells;
center
Journal Title: European Journal of Immunology
Year Published: 2019
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Journal Title: European Journal of Immunology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!