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We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare… Click to show full abstract
We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare them to previously published α2- and γ1-specific mice. These mice may help enlighten key aspects of celiac disease pathogenesis.
Keywords:
dq2;
recognizing immunodominant;
receptor transgenic;
characterization cell;
cell receptor;
mice
Journal Title: European Journal of Immunology
Year Published: 2020
Link to full text (if available)
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Journal Title: European Journal of Immunology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!