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Mesoporous silica microspheres have been functionalized with triazole and pendant hydroxyl moieties by post synthetic procedure. The functionalities have been prepared by a very efficient azide alkyne click reaction with… Click to show full abstract
Mesoporous silica microspheres have been functionalized with triazole and pendant hydroxyl moieties by post synthetic procedure. The functionalities have been prepared by a very efficient azide alkyne click reaction with propargyl alcohol to yield the corresponding 1,2,3-triazole. The subsequent reaction with cis-platinum and titanocene as metallic precursors produces platinum and titanium complexes tethered onto the silica surface. The synthesized materials have been fully characterized by DRX, FT-IR, N2 adsorption-desorption techniques, TEM, DRUV-vis and 13C CP/MAS NMR spectroscopy. In addition, the interaction of these materials with molecules of biological interest such as guanosine and bovine serum albumin has been studied by means of solid state voltammetry techniques. Drug release experiments in simulated body fluid shows sustained release profiles for platinum complexes
Journal Title: European Journal of Inorganic Chemistry
Year Published: 2017
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