LAUSR

Both pumpkin and kenaf seed oil with carnauba wax (CW) and beeswax (BW) are used to develop nanostructured lipid carriers (NLCs) loaded with Uvinul T150 and Uvinul A Plus Granular for a UV protection formulation. The study aims to optimize the concentration and the type of seed oil in order to develop a stable NLC formulation with high entrapment efficiency, drug loading, antioxidant activities, and UV absorbing properties. The physical properties of the NLCs are analyzed based on the mean particle size, polydispersity index (PDI), long‐term storage stability, Fourier‐transform infrared spectroscopy (FT‐IR), and differential scanning calorimetry (DSC). They are also compared for their entrapment efficiency, drug loading, in vitro antioxidant activities, and in vitro UV absorbing properties. The optimized NLC consists of 10% lipid phase and 1% Uvinul T150 and Uvinul A Plus Granular, respectively. It has mean particle size of 238.20 ± 3.61 nm and remains physically stable on storage at both 25 ± 2 and 40 ± 2 °C. Spherical amorphous NLC structure with encapsulated UV filters is observed by transmission electron microscopy (TEM). Besides, it shows high entrapment efficiency (≥95%) for both Uvinul T150 and Uvinul A Plus Granular in addition to its antioxidant activities as indicated by both DPPH and ABTS radical scavenging activities. In addition, the formulation had high UV absorbing properties, showing its potential to be utilized in the formation of sunscreen prototype. Practical Application: The preliminary study on pumpkin and kenaf seed oil shows bioactive potential with high antioxidant activities. The finding of kenaf seed oil‐NLC can be applied in the cosmetic industry to produce a wide variety of environmental‐friendly products with improved stability and beneficial properties. Also, the application of technology by forming NLCs can be used to develop lotions, creams, etc., with multifunctional properties. Besides, NLCs as carriers for UV filters is proven in the present study to exhibit high entrapment efficiency and drug loading properties. This is beneficial in developing advanced cosmetic prototypes that possess broad spectrum effectiveness with fewer side effects. Nanostructure lipid carriers (NLCs) are applied to encapsulate UV filters with pumpkin and kenaf seed oils. Kenaf seed oil‐NLC (F7) is selected as the best formulation for UV filters encapsulation. With spherical amorphous NLC structure, it shows high entrapment efficiency for the UV filters and antioxidant activities. Results indicate that F7 with high UV absorbing properties remains physically stable upon 12 weeks of storage period.