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A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis… Click to show full abstract
A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a tandem-type, one-pot process. A key feature of this one-pot synthesis is the high 500 mM loading of the aldehyde substrate used as a starting material.
Keywords:
diastereoselective synthesis;
synthesis diols;
process;
one pot
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!