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A direct comparison of N- vs. O-methyloxyamine linkers for carbohydrates is presented, include optimised synthetic routes, glycan conjugations and studies into hydrolytic stabilities. From this work we demonstrate that pH,… Click to show full abstract
A direct comparison of N- vs. O-methyloxyamine linkers for carbohydrates is presented, include optimised synthetic routes, glycan conjugations and studies into hydrolytic stabilities. From this work we demonstrate that pH, glycan concentration and buffer strength influence hydrolysis rates, and provide insight into the acid catalysed hydrolysis mechanism.
Keywords:
methyloxyamine linkers;
stability methyloxyamine;
linkers synthesis;
hydrolytic stability;
methyloxyamine;
synthesis hydrolytic
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!