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Heteroaryllithium compounds, obtained by MesLi-mediated halogen/lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron-rich (thiophenyl) and electron-deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation… Click to show full abstract
Heteroaryllithium compounds, obtained by MesLi-mediated halogen/lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron-rich (thiophenyl) and electron-deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation of six- and seven-membered rings, providing an efficient route to fused indolizines and pyrroloazepines in moderate to good yields.
Keywords:
addition heteroaryllithium;
indolizines pyrroloazepines;
heteroaryllithium compounds;
intramolecular addition
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!