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Metal‐Free trans‐Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone

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Herein, we describe a metal-free, iodosobenzenediacetate mediated trans-aziridination of zerumbone by the direct use of sulphonamides. The preliminary in vitro-screening showed better anti-proliferative and anti-diabetic activity compared to parent compound… Click to show full abstract

Herein, we describe a metal-free, iodosobenzenediacetate mediated trans-aziridination of zerumbone by the direct use of sulphonamides. The preliminary in vitro-screening showed better anti-proliferative and anti-diabetic activity compared to parent compound zerumbone.

Keywords: free trans; aziridination zerumbone; trans aziridination; metal free; synthesis biological; zerumbone synthesis

Journal Title: European Journal of Organic Chemistry
Year Published: 2017

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