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Chiral-at-metal Rh(III) complexes catalyzed highly efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes is developed, affording the corresponding adducts in 81-99% yields with up to >99% enantioselectivities. This protocol… Click to show full abstract
Chiral-at-metal Rh(III) complexes catalyzed highly efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes is developed, affording the corresponding adducts in 81-99% yields with up to >99% enantioselectivities. This protocol performs with 0.1 mol % of Rh(III) complex on gram scale without loss in enantioselectivity.
Keywords:
chiral metal;
enantioselective mannich;
mannich reaction;
reaction employing
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!