LAUSR

A new strategy has been developed for the first time for the synthesis of spirofluorenyl benzosultams through the annulation of aryl iodides with cyclic N-sulfonyl ketimines. This method involves a readily available Pd(II) catalyst for the activation of aryl C-H bonds to facilitate the annulation process. In contrast, Pd is relatively cheaper than other transition metal catalysts such as Ir and Rh used for the C-H activation. This approach leads to the synthesis of biologically relevant spiro-benzosultams in a single step process.