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Ultrasound promoted enantioselelctive decarboxylative protonation reaction of α-aminomalonate hemiesters 1 in the presence of chiral cinchona-derived squaramide Bronsted bases under mild conditions afforded both the (S) and (R) enantiomers of… Click to show full abstract
Ultrasound promoted enantioselelctive decarboxylative protonation reaction of α-aminomalonate hemiesters 1 in the presence of chiral cinchona-derived squaramide Bronsted bases under mild conditions afforded both the (S) and (R) enantiomers of α-amino acid derivatives 2 in excellent yields (>90%) and excellent enantioselectivities (up to 98% ee).
Keywords:
enantiomers amino;
aminomalonate hemiesters;
ultrasound promoted;
decarboxylative protonation
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!