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Isocyanide-Based Multicomponent Reaction to Approach N-H Functionalization of Indole Using N-Acyliminium Ion as Key Intermediate

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The present work discloses an efficient multicomponent reaction of isocyanide, allenoate, and indole. In the absence of any catalyst, this protocol provides a rapid and direct access to furnish N-H… Click to show full abstract

The present work discloses an efficient multicomponent reaction of isocyanide, allenoate, and indole. In the absence of any catalyst, this protocol provides a rapid and direct access to furnish N-H functionalization of indole from readily available starting materials. This strategy also features the broad substrate scope and mild conditions.

Keywords: isocyanide based; functionalization indole; multicomponent reaction

Journal Title: European Journal of Organic Chemistry
Year Published: 2017

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