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Solvent-free synthesis of cyanoformamides from carbamoyl imidazoles

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A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the… Click to show full abstract

A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.

Keywords: free synthesis; cyanoformamides carbamoyl; synthesis cyanoformamides; carbamoyl imidazoles; solvent free

Journal Title: European Journal of Organic Chemistry
Year Published: 2017

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