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(±)-Pregabalin has been synthesized by utilizing flow methods. Three-step sequential-flow reactions starting from commercial isovaleraldehyde and methyl malonate proceeded smoothly with heterogeneous catalysts to afford the desired compound. The total… Click to show full abstract
(±)-Pregabalin has been synthesized by utilizing flow methods. Three-step sequential-flow reactions starting from commercial isovaleraldehyde and methyl malonate proceeded smoothly with heterogeneous catalysts to afford the desired compound. The total yield was 75%-quant, and a space-time yield (STY) of 52.2 g/L·d was reached. In addition, a heterogeneous catalyst for the Knoevenagel reaction of aldehydes with malonates, which is the first step of the synthesis, has been developed.
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
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