LAUSR

Three novel aryl boronate ester based amino acids are described. These useful building blocks were found to exhibit all of the chemical properties compatible to the Fmoc strategy solid-phase peptide synthesis and orthogonal to Boc, tBu, Pbf and Trt groups. Their effective application for synthesis of different types of peptidomimetics has been demonstrated by high-quality preparation of lipidated peptide MP-196 C-C8, on-resin head-to-tail cyclization of desotamide B and lactam bridging of hPTHrP-(11-19) through a facile and metal-free procedure by standard Fmoc-assisted solid-phase peptide synthesis.