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The TEMPO-mediated oxidative deformylation of aldehydes is reported that yields the TEMPO adducts which can be further oxidized to the corresponding ketones. The focus of this work was on the… Click to show full abstract
The TEMPO-mediated oxidative deformylation of aldehydes is reported that yields the TEMPO adducts which can be further oxidized to the corresponding ketones. The focus of this work was on the optimization of a synthetic protocol for use in natural product synthesis, specifically for the preparation of chiral backbones with 1,2-oxo functionalization found in polyketide antibiotics. In addition, the oxidative deformylation was combined with the oxidation of the alcohol to the precursor aldehyde in a one-pot protocol.
Keywords:
deformylation aldehydes;
mediated oxidative;
oxidative deformylation;
aldehydes applications;
tempo mediated;
deformylation
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!