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The asymmetric total synthesis of optically pure (–)-gracilamine (1) was achieved by employing a bioinspired approach. The strategy involved elaboration of 3a-arylhexahydroindole 7, a designed precursor, to 3a-formylarylhexahydroindole 5, which… Click to show full abstract
The asymmetric total synthesis of optically pure (–)-gracilamine (1) was achieved by employing a bioinspired approach. The strategy involved elaboration of 3a-arylhexahydroindole 7, a designed precursor, to 3a-formylarylhexahydroindole 5, which upon heating with l-leucine ethyl ester gave (–)-1 efficiently.
Keywords:
asymmetric total;
total synthesis;
gracilamine;
bioinspired approach
Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!