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A mild domino rearrangement strategy for the direct access to substituted quinoline‐4‐carboxamides has been developed. This copper‐catalyzed coupling reaction of O‐acyl oximes with isatins in the presence of molecular oxygen… Click to show full abstract
A mild domino rearrangement strategy for the direct access to substituted quinoline‐4‐carboxamides has been developed. This copper‐catalyzed coupling reaction of O‐acyl oximes with isatins in the presence of molecular oxygen as the sole oxidizing agent proceeds through a ring expansion of the isatins through cleavage of the two CN bonds
Keywords:
strategy direct;
quinoline carboxamides;
domino rearrangement;
direct access;
catalyzed coupling;
rearrangement strategy
Journal Title: European Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!