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A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and… Click to show full abstract
A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different Michael acceptors. Additionally, the reaction products can be further functionalized, showing an excellent perspective for future applications.
Keywords:
water;
water compatible;
synthesis trifluoromethyl;
trifluoromethyl dioxanes;
compatible synthesis
Journal Title: European Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!