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The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with… Click to show full abstract
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
Keywords:
flow synthesis;
phenothiazine;
continuous flow;
phenothiazine antipsychotics;
synthesis phenothiazine
Journal Title: European Journal of Organic Chemistry
Year Published: 2019
Link to full text (if available)
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Journal Title: European Journal of Organic Chemistry
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!