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Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the… Click to show full abstract
Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corresponding fluoro‐acetophenone, ‐1,3‐ketoester, ‐1,3‐diketone and ‐pyran‐4‐one products respectively from the same selectively fluorinated scaffold in one‐step procedures.
Keywords:
fluorinated building;
building blocks;
fluorotricarbonyl derivatives;
derivatives versatile;
blocks synthesis;
versatile fluorinated
Journal Title: European Journal of Organic Chemistry
Year Published: 2020
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Journal Title: European Journal of Organic Chemistry
Year Published: 2020
Link to full text (if available)
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recommendations!