A tetrahydrothiopheno equatorial substituent on a glycoluril moiety of a cucurbit[n]uril was found to be robust and provided a capacity for reactive derivatization. We have demonstrated this on tetrahydrothiopheno substituted… Click to show full abstract
A tetrahydrothiopheno equatorial substituent on a glycoluril moiety of a cucurbit[n]uril was found to be robust and provided a capacity for reactive derivatization. We have demonstrated this on tetrahydrothiopheno substituted glycoluril derivatives as a proof of concept, then translatable reactions were applied to tetrahydrothiopheno substituted cucurbituril homologues 7 and 8. In addition to the successful derivatization tetrahydrothiophenocucurbit[7 and 8]uril, some new glycoluril derivatives have been synthesized, which may serve as future precursors for the synthesis of other substituted cucurbit[n]uril and their analogues.
Journal Title: European Journal of Organic Chemistry
Year Published: 2025
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