We report the first synthesis of pentafluorosulfanylated oxazoles through a gold(I) catalyzed cyclization of SF5‐alkynes and nitriles. We describe 17 examples of 4‐SF5‐oxazoles with NMR yield ranging from 3% to… Click to show full abstract
We report the first synthesis of pentafluorosulfanylated oxazoles through a gold(I) catalyzed cyclization of SF5‐alkynes and nitriles. We describe 17 examples of 4‐SF5‐oxazoles with NMR yield ranging from 3% to 75%. While the isolation of the pure pentafluorosulfanylated oxazoles proved challenging, the fluorinated heterocycles could nonetheless be obtained in yields between 14 and 52%, opening the door for their use as a novel fluorine‐containing scaffold.
Keywords:
catalyzed synthesis;
oxazoles gold;
synthesis substituted;
substituted pentafluorosulfanyl;
gold catalyzed;
pentafluorosulfanyl oxazoles
Journal Title: European Journal of Organic Chemistry
Year Published: 2025
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Journal Title: European Journal of Organic Chemistry
Year Published: 2025
Link to full text (if available)
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