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Substance P (SP) is a pain‐ and inflammation‐related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and… Click to show full abstract
Substance P (SP) is a pain‐ and inflammation‐related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this study was to test if genetic variation at the neurokinin 1 receptor gene (TACR1) is associated with pain in individuals with radiographic knee OA.
Keywords:
receptor;
substance;
pain;
variation neurokinin
Journal Title: European Journal of Pain
Year Published: 2017
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Journal Title: European Journal of Pain
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!