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Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway

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Spinal cord injury (SCI) causes continuous neurological deficits and major sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor function following SCI. Thus, it is crucial to develop novel… Click to show full abstract

Spinal cord injury (SCI) causes continuous neurological deficits and major sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor function following SCI. Thus, it is crucial to develop novel therapeutics for this particular patient population. Astaxanthin (AST) is a strong antioxidant, anti‐inflammatory and anti‐apoptotic agent. In the present study, it was tested in a severe compression SCI model with emphasis on sensory‐motor outcomes, signalling pathway, along with other complications.

Keywords: motor function; sensory motor; signalling pathway; motor; cord injury; spinal cord

Journal Title: European Journal of Pain
Year Published: 2019

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