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Nociceptive pain remains a prevalent clinical problem and often poorly responsive to the currently available analgesics. Previous studies have shown that astroglial glutamate transporter‐1 (GLT‐1) in the hippocampus and anterior… Click to show full abstract
Nociceptive pain remains a prevalent clinical problem and often poorly responsive to the currently available analgesics. Previous studies have shown that astroglial glutamate transporter‐1 (GLT‐1) in the hippocampus and anterior cingulate cortex (ACC) is critically involved in pain processing and modulation. However, the role of astroglial GLT‐1 in nociceptive pain involving the hippocampus and ACC remains unknown. We investigated the role of 3‐[[(2‐Methylphenyl) methyl]thio]‐6‐(2‐pyridinyl)‐pyridazine (LDN‐212320), a GLT‐1 activator, in nociceptive pain model and hippocampal‐dependent behavioural tasks in mice.
Journal Title: European Journal of Pain
Year Published: 2019
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