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P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of… Click to show full abstract
P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of P2X7 receptor signalling in pain, and the lack of a corresponding preclinical mechanistic biomarker.
Keywords:
p2x7 receptor;
receptor mediated;
release microglial;
mediated release;
microglial prostanoids;
receptor
Journal Title: European Journal of Pain
Year Published: 2022
Link to full text (if available)
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Journal Title: European Journal of Pain
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!