LAUSR

Daptomycin was the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and presents a broad spectrum of activity against a wide range of gram-positive bacteria. The daptomycin redox behaviour, by cyclic, differential pulse and square wave voltammetry, in a wide pH range, at a glassy carbon electrode, was investigated. The daptomycin oxidation was a two-step irreversible diffusion-controlled process and the diffusion coefficient DDPT = 2.32 3 10 5 cm s , was calculated. A detection limit LOD = 0.32 mM, was obtained. For the first time daptomycin, in fetal bovine serum biological fluid, using DP voltammetry, was determined.