LAUSR

We aimed to explore the action of a circRNA produced by ring finger protein 10 (circ_RNF10; hsa_circ_0028899) in the malignant behaviors of breast cancer (BC) and to explore its potential action‐of‐mechanism. The levels of circ_RNF10, miR‐942‐5p and Golgi integral membrane protein 4 (GOLIM4) were measured through quantitative real‐time polymerase chain reaction, western blot, or immunohistochemistry, and the competing endogenous RNA (ceRNA) relationship among them was verified by dual‐luciferase reporter assay. Cell counting kit‐8, 5‐ethynyl‐2′‐deoxyuridine, and colony formation assays, transwell assays, and flow cytometry were used to examine cell proliferation, migration and invasion, and apoptosis, respectively. Levels of proliferation and invasion‐related markers were determined by western blot. Xenograft assay was performed to assess tumor growth. Circ_RNF10 level was significantly reduced in BC tissues and cells. Elevation of circ_RNF10 blocked BC cell proliferation, migration and invasion while promoted the apoptosis in vitro, companied with decreased PCNA and Twist1 and increased E‐cadherin. Furthermore, upregulating circ_RNF10 delayed tumor growth of BC cells in nude mice. Mechanistically, circ_RNF10 acted as a ceRNA for miR‐942‐5p, and miR‐942‐5p could target GOLIM4. In addition, miR‐942‐5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression. Furthermore, GOLIM4 silencing attenuated the inhibitory effect of miR‐942‐5p knockdown on BC progression. We found that circ_RNF10 suppressed BC malignant behavior by targeting miR‐942‐5p/GOLIM4 axis.